Fig. 1

ORP1-ORD transfers cholesterol but not PIPs. a Schematic diagram of human ORP1L and ORP1S. The structural elements in ORD are colored as follows: N-terminal loop (blue), lid (magenta), core (yellow). The color scheme of ORP1-ORD is consistent throughout the schematic representations unless indicated. b Lipid-binding analyses for ORP1-ORD. c DHE transport assays without or with PIP in the acceptor liposomes. Shown at the bottom are the initial velocities of DHE transport subtracted by that without ORP1. d PIP transport assays with DHE-containing acceptor liposomes. (For all bar graphs, data are shown as mean ± s.e.m. (error bar), n = 3)