Fig. 4

Structures of cholesterol-bound ORP1-ORD in open conformations. a, b Overall structures of ORP1-ORD in complex with cholesterol at 2.6 Å (a) and at 3.4 Å (b). The cholesterol ligand is highlighted as green stick. c Detailed binding mode of cholesterol in the 2.6 Å structure. For clarity, part of the structure has been removed to show the ligand-binding tunnel. Dashed line, polar interaction