Fig. 4
From: Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo
IPGTT studies in mice. a–d Intraperitoneal glucose tolerance test (IPGTT) at different time after dosing in fasted normal mice (C57BL/6J, male, 20–25 g). Dosage: 200 μg kg−1 (50 nmol kg−1) i.v. Formulation: 20 μg mL−1 in PBS 1×. IPGTT: glucose 2 g kg−1 i.p. at T0. a IPGTT after 5 min (n = 4). b IPGTT after 30 min (n = 6). c IPGTT after 2 h (n = 6). d IPGTT after 4 h (n = 3). Area under the curve (AUC) of the corresponding IPGTT curve. Data are mean ± SEM. Statistic by two-way ANOVA and Bonferroni post-test: *p < 0.05, **p < 0.01, ***p < 0.001, comparing vehicle to oligomers; one-way ANOVA with Dunnett’s multiple comparison test: ##p < 0.01, ###p < 0.001, comparing vehicle to oligomers. Source data are provided as a Source Data file
