Fig. 6
From: Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo
Blood glucose study in db/db mice. a Blood glucose concentration in db/db mice (male, 40–45 g, n = 5) before and after dosing: 200 μg kg−1 (50 nmol kg−1) intraperitoneal. Formulation: 20 μg mL−1 in PBS 1×. The dosing was done at T0. AUC of the IPGTT curves. b Pancreatin degradation assay (n = 3). Data are mean ± SEM. Statistic by two-way ANOVA and Bonferroni post-test: *p < 0.05, **p < 0.01, ***p < 0.001, comparing vehicle to oligomers; one-way ANOVA with Dunnett’s multiple comparison test: #p < 0.05, ###p < 0.001, comparing vehicle to oligomers; two-way t-test: £££p < 0.001, comparing semaglutide to hybrid 24. Source data are provided as a Source Data file
