Table 1 Bioactivity of GLP-1 and cognate peptide–oligourea analogues in cAMP production functional assay

From: Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo

  1. Oligourea inserts (triads and hexads) are shown as green boxes. The highlighted amino acids in the GLP-1 sequence generated the highest decrease of activity in the Ala scan: red = very high decrease, orange = high decrease. Unless otherwise stated, the data are EC50 values ± SE obtained by non-linear regression on 8 points concentration–response curves performed in duplicates (n = 2). Source data are provided as a Source Data file
  2. EC50 half maximal effective concentration, cAMP cyclic adenosine monophosphate
  3. aGLP-1R potency (EC50)
  4. bStandard error (SE) on the EC50
  5. cPercentage of potency compare to GLP-1-G2
  6. dMean value of 26 experiments
  7. eStandard error of the mean (SEM) on the EC50
  8. fMean value of four experiments.
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