Fig. 2
From: A network-centric approach to drugging TNF-induced NF-κB signaling
Thermal shifts indicate dose-dependent stabilization of TRAF2 by compounds 2 and 3. Normalized melt curves (left) and melting temperature (ΔTm; right) of full-length TRAF2 were recorded in the presence of dimethyl sulfoxide or indicated concentrations of a compound 2 (tan lines) and b compound 3 (teal lines). The rightward shift of the melt curve in the presence of compounds, quantified by the ΔTm in two replicate experiments, suggest increased thermal stability of the protein–compound complex. Source data are provided as a Source Data file
