Table 2 Clinical Characteristics of the patients administrated with pembrolizumab

From: The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

Characteristics

Case, n

PR, n

SD, n

PD, n

P-value

Gender

     

 Male

26

7

5

12

1

 Female

11

 

4

4

 

Smoking

     

 Smoker

19

6

3

9

1

 Non-smoker

18

1

6

7

 

Age

     

 <65

31

5

7

14

0.36

 ≥65

6

2

2

2

 

Histology

     

 Adenocarcinoma

23

5

5

9

0.52

 Squamous-cell carcinoma

11

2

2

6

 

 Others

3

 

2

1

 

TNM stage

     

 I

1

 

1

 

0.93

 II

2

  

2

 

 III

3

2

 

1

 

 IV

30

5

8

12

 

 Unknown

1

  

1

 

AhR IRS

     

 ≥4

21

7

6

4

0.001

 <4

16

0

3

12

 

No. of TMB

     

 ≥7

19

3

3

10

0.20

 <7

15

2

6

5

 

Unknown

3

2

 

1

 
  1. PR partial response, SD stable disease, PD progression of disease, P value patients achieved PR and SD versus cases with PD
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