Fig. 2 | Nature Communications

Fig. 2

From: Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire

Fig. 2

CDR3 length dependent amino acid usage. a, b The frequencies of amino acids in FG-loops of CDR3β (a) and CDR3α (b) in B6, Q and QB repertoires with respect to their CDR3 length. c Cys usage of CDR3β (left panel) and CDR3α (right panel) is significantly lower in MHCr repertoires than MHCi repertoires. Our analysis excludes a germline-encoded CDR3 cysteine present in several mouse Vβ gene families because that cysteine is not in the FGβ-loop and does not contact peptide-MHC. d Usage of charged and hydrophobic amino acid usages of MHCr repertoires and MHCi repertoires

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