Table 1 SNPs significantly associated with carpal tunnel syndrome
Chromosome | Positiona | rsID | Effect allele | EAF casesb | EAF controlsc | Infod | OR (95% CI) | p Value | Mapped genese |
|---|---|---|---|---|---|---|---|---|---|
1 | 103240351 | rs12406439 | T | 0.605 | 0.587 | 0.995021 | 1.08 (1.05–1.11) | 1.10 × 10−8 | COL11A1 |
2 | 33413303 | rs12104955 | C | 0.517 | 0.499 | 0.994032 | 1.07 (1.05–1.10) | 3.90 × 10−8 | LTBP1 |
2 | 56096892 | rs3791679 | G | 0.244 | 0.225 | G | 1.11 (1.08–1.15) | 2.00 × 10−12 | EFEMP1 |
2 | 60175475 | rs1025128 | C | 0.582 | 0.563 | 0.988458 | 1.08 (1.05–1.11) | 2.80 × 10−9 | – |
2 | 176900271 | rs847139 | C | 0.805 | 0.787 | 0.985197 | 1.11 (1.07–1.14) | 7.20 × 10−11 | KIAA1715, EVX2 |
2 | 218128152 | rs1863190 | T | 0.78 | 0.76 | 0.997145 | 1.12 (1.08–1.15) | 5.40 × 10−13 | DIRC3 |
3 | 124450081 | rs4678145 | G | 0.88 | 0.868 | 0.999293 | 1.12 (1.08–1.16) | 4.10 × 10−9 | ITGB5, UMPS, KALRN, MUC13 |
4 | 13221747 | rs6843953 | T | 0.154 | 0.138 | 0.99611 | 1.14 (1.10–1.18) | 5.80 × 10−12 | – |
6 | 31440651 | rs3828889 | C | 0.748 | 0.732 | 0.996908 | 1.09 (1.06–1.12) | 1.70 × 10−8 | – |
6 | 85715955 | rs62422907 | G | 0.899 | 0.887 | 0.991783 | 1.13 (1.09–1.18) | 2.20 × 10−9 | – |
7 | 44145178 | rs55841377 | C | 0.789 | 0.773 | 0.992012 | 1.09 (1.06–1.13) | 8.40 × 10−9 | AEBP1, PLD2, MYL7, GCK |
7 | 150542515 | rs6977081 | G | 0.685 | 0.668 | 0.97855 | 1.08 (1.05–1.11) | 1.20 × 10−8 | AOC1, TMEME176A, KCNH2, TMEM176B |
14 | 76245906 | rs72725608 | C | 0.051 | 0.044 | G | 1.20 (1.13–1.27) | 1.10 × 10−8 | IFT43, TTLL5, TGFB3 |
15 | 67034812 | rs1866745 | A | 0.369 | 0.35 | 0.993487 | 1.09 (1.06–1.12) | 4.20 × 10−10 | SMAD6 |
15 | 100692953 | rs72755233 | A | 0.128 | 0.112 | G | 1.18 (1.13–1.22) | 2.30 × 10−15 | ADAMTS17 |
19 | 8670147 | rs62621197 | T | 0.045 | 0.036 | 0.924188 | 1.31 (1.22–1.40) | 7.50 × 10−14 | ADAMTS10, MYO1F |
