Table 3 Mendelian randomisation study of height and CTS

From: A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome

 

Method

Odds ratio (95% CI) of CTS per 1-SD higher height

p value

Main analysis

IVW

0.79 (0.74, 0.83)

2.24 × 10–15

 

Weighted median

0.80 (0.75, 0.86)

2.33 × 10–9

 

MR-Eggera

0.72 (0.61, 0.84)

2.87 × 10–5

Sensitivity analysis

IVW

0.80 (0.75, 0.85)

9.88 × 10–15

 

Weighted median

0.81 (0.76, 0.87)

7.86 × 10–9

 

MR-Eggerb

0.74 (0.64, 0.86)

7.89 × 10–5

  1. The main analysis included 601 SNPs from Wood et al.37, and the sensitivity analysis was performed after removing 5 SNPs that were significant in both the height and CTS GWAS. The mean height for the whole cohort (both sexes combined) was 168.7 cm; SD = 9.24 cm
  2. CTS carpal tunnel syndrome, GWAS genome-wide association study, IVW inverse variance-weighted
  3. aMR-Egger intercept (95% CI): 0.00296 (–0.00163, 0.00756); p = 0.21
  4. bMR-Egger intercept (95% CI): 0.00244 (–0.00194, 0.00681); p = 0.28
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