Fig. 4
Comparison of the fibril structure and the native VL domain fold. a Comparison of the native VL domain fold (PDB entry 1BJM)60 with the fibril state. Residues 15–105 are shown in rainbow color. The native conformation is truncated at residue 118, corresponding to our fibril protein. The diffuse N-terminal and C-terminal tails of the fibril structure are schematically added with a gray line. b Part of the native structure and of the fibril state showing the conformational switch of segments 86–93 and 16–23 relative to one another around the protein disulfide bond. c Schematic representation of the hypothetical misfolding reaction consisting of an unfolding reaction (1), the rotational switch (2) and the assembly into the fibril structure (3)
