Fig. 2 | Nature Communications

Fig. 2

From: Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

Fig. 2

Different handedness of the β-sheet twist in the murine and the human fibril. a TEM images of murine (left) and human (right) AA amyloid fibrils after platinum side shadowing (scale bar: 50 nm). b Left-hand β-sheet twist of the murine fibril illustrated for sheet β1 (orange) and right-hand twist of the β-sheet of the human fibril illustrated for β2 (cyan). Every tenth molecule along the fibril axis displayed. c Ramachandran plot of all residues within the β-strands of human (cyan), murine fibril (orange) and in the globular protein of phosphoglycerate kinase (green). d Ribbon diagram illustrating the left-hand β-sheet twist of human phosphoglycerate kinase (PDB 3C39, residues 1–202)

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