Fig. 5
Interactions between the two protein stacks in the murine and human fibril. a Cross-sectional view of four molecular layers of the murine fibril with a close-up on the stack-stack interface. b Side view showing the ladder of ionic residues which make bidentate interactions between the two murine protein stacks. c Cross-sectional view of four molecular layers of the human fibril with a close-up on the interface between the protein stacks. d Cross-stack steric zipper formed by β-sheet β3 (residues Tyr29 and Ile 30) of the human fibril. e Cross-stack interactions between the α-amino group of Ser2 and the side chain carboxyl group of Asp33 from the other protein stack
