Fig. 7
From: Inner lumen proteins stabilize doublet microtubules in cilia and flagella
A schematic model of MIP3. a Isosurface rendering of the wild type density map. MIP3a-c is highlighted as shown in Fig. 2 (MIP3a: yellow; MIP3b: orange; MIP3c: green). The right map is the longitudinal view sliced by the line in the left map. A possible unit of MIP3c is circled in red. Scale bar = 25 nm. b A model of DMT stabilization. FAP45 (green) and FAP52 (yellow) are localized on the inner lumen of the B-tubule and stabilize the MT wall. In particular, FAP45 ties protofilaments B7–B9. FAP52 anchors B9 and B10 to A13 and binds to FAP45. Thus, these proteins strengthen the MT wall against DMT-bending. Loss of both proteins leads to destabilization of the B-tubule and the B-tubule is depolymerized by bending
