Fig. 2
B cell action following tissue injury in human allografts. a, e Scatter plot showing the estimated glomerular filtration rate (eGFR) at 3 months (a, N = 41) and 12 months (e, N = 39) in kidney transplant recipients classified in the CKI and non-CKI group at 12 months. Unpaired t test, *P < 0.05. b, f, g Scatter plots showing the histological evaluation of protocol biopsies according to Banff at 3 months (b) and 12 months (f, g). t acute tubular lesions, ci chronic interstitial lesions, ct chronic tubular lesions, ptc peritubular capillaritis, C4d-ptc Cd4 positivity in peritubular capillaries. Mann–Whitney test, **P < 0.01. c Histograms showing mean RPKM values and SE of representative genes related to kidney injury and repair from kidney biopsies collected at 3 months after transplantation. Mann–Whitney test, *P < 0.05, **P < 0.01. Red symbols indicate patients of the CKI-group, blue symbols of the non-CKI group. Empty and filled symbols show data acquired at 3 and 12 months after transplantation, as indicated. d Gene enrichment analysis including genes with a higher expression in the MIR group at 3 months, among genes previously associated with acute rejection episodes. P values adjusted according to Benjamini–Hochberg
