Fig. 3
From: DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy
DNA shell selection. a Snapshots of (i) HS-(PO)TCGCGC-Cy7, (ii) HS-(PO)A6-Cy7, (iii) HS-(PS)A6-Cy7 DNA folding onto 1.2 nm AuNP surface at different time points of molecular dynamics simulations. Color coding, green: Cy7, orange: 3′ residue, blue: 5′ residue, red balls: O-atoms, yellow balls: S-atoms, gray: Au atoms. b The AuNP surface-fluorophore distance distributions of HS-(PO)A6-Cy7 (blue, daverage = 0.97 nm), HS-(PS)A6-Cy7 (red, daverage = 0.92 nm), and HS-(PO)TCGCGC-Cy7 (black, daverage = 1.22 nm) at equilibrium showing very close proximity of the fluorophore to the AuNP surface for first two sequences. c Specifications of the 4 different DNA sequences functionalized with DylightTM-780 fluorophores. d The baseline-subtracted Raman-spectra of FRNPs (10 fM) derived from the sequences A–D demonstrating that FRNPs derived from sequence D have the highest signal intensity
