Fig. 7
From: UFL1 promotes histone H4 ufmylation and ATM activation
Model for ATM activation by UFL1. When DNA damage occurs, UFL1 is recruited by MRN complex and monoufmylates histone H4, thus recruiting SUV39H1 to DSBs to trimethylate H3K9 thereby forming H3K9me3. Tip60 binds to H3K9me3, acetylates ATM, and promotes ATM activation. C-Abl also phosphorylates Tip60 and enhances Tip60 acetyltransferase activity. Activated ATM phosphorylates UFL1 at Ser462, and enhances its activity thereby amplifying ATM activation signal and forming a positive feedback loop
