Table 1 The EC50s of listed compounds with either single or combined treatment

From: Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

Cell

Singlea

CB-839

(μM)

Singlea

metformin

(mM)

Combinedb

CB-839

(μM)

Combinedb

metformin

(mM)

TE7 (D1P287A)c

4.75

7.29

0.75

1.20

TE10 (Fbxo4 S8R)c

5.05

8.37

0.92

1.47

TE15 (WT D1)c

16.52

9.88

1.77

2.83

TE7PDR

0.23

3.64

0.09

0.144

TE10PDR

0.21

3.78

0.09

0.144

  1. aSingle, single treatment with CB-839 or metformin
  2. bCombined, combined treat with both CB-839 and metformin
  3. cFor TE7, TE10, and TE15 cells, the information in the parentheses indicates gene status
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