Fig. 6
From: Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
Model polymer simulation shows that the attachment to the NL is sufficient for chromatin compaction. a Scheme of the model polymer (MP) and visualisation of its conformation derived from a simulation run. Blue particles are able to interact with each other and with the surface recapitulating properties of non-acetylated nucleosomes in the inactive chromatin. Orange particles are unable to interact with any particles and with the surface recapitulating properties of acetylated nucleosomes in active chromatin. MP is composed of 68 blue and 68 orange particle blocks. Blue blocks with at least one particle contacting the surface are coloured with dark blue and considered as LADs. b The number of spatial contacts between particles in a blue block depends positively on the number of particles in this block contacting the surface. Trend line is in red. c The volume of a blue block depends inversely on the number of particles in this block contacting the surface. Trend line is in red. d Averaged 3D structures of blue blocks with a different number of contacts with the surface (left panel). Box plots (see Fig. 1g legend for description of their elements) show the decrease of LAD volume with the increasing number of contacts with the surface (right panel). ****P < 0.0001, ***P < 0.001, **P < 0.01, NS non-significant difference (P > 0.05) in a Wilcoxon test. e Illustrative representation of key observations made in this work
