Fig. 9
From: Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation
Multiple roles of RAD52 at perturbed replication forks. Model representing multiple roles of RAD52 at perturbed replication forks. In response to replication fork perturbation, RAD52 plays crucial roles both upstream replication fork remodelling and downstream, when integrity of remodelled forks is undermined. The role upstream replication fork remodelling is crucial to limit reversal of replication fork, which may be deleterious if unscheduled. These two independent roles of RAD52 are carried out also through distinct protein partners, and may be relevant under either normal or pathological replication perturbation (see text for details)
