Fig. 7
From: NKG2A is a NK cell exhaustion checkpoint for HCV persistence
Anti-NKG2A restored T cell response through enhanced IFN-γ production. a FACS analysis of hepatic IFN-γ positive cells with or without NKG2A blockade 2 wpi. b, c C/OTg mice (n = 6 each group) were i.p. pre-treated with IFN-γ neutralization antibody or isotype IgG (100 μg/3 days) together with anti-NKG2A antibody 1 d before HCV inoculation. b HCV-specific CD8+ T cell response by IFN-γ ELISpot and c serum and hepatic HCV RNA copies were measured 2 wpi. d Diagram of Qa-1/NKG2A immune checkpoint during HCV infection. Dash lines indicated limits of detection of related assays. Data were mean ± SD, Student t-test. *P < 0.05; **P < 0.01. Source data are provided as a Source Data file
