Fig. 1 | Nature Communications

Fig. 1

From: Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids

Fig. 1

Challenges in stereocontrolled Csp3 couplings. a Stereoselective couplings vs. stereospecific couplings. b Competing stereodivergent stereospecific transmetalation pathways. c Axial shielding—a ligand design principle for controlling stereochemistry in Csp3 couplings. Projecting steric bulk above and below the Pd (II) square plane should selectively inhibit stereoinvertive transmetalation, thus favoring stereoretention

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