Fig. 2 | Nature Communications

Fig. 2

From: Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids

Fig. 2

Tuning of ligand sterics. a Crystal structure of {[(2-Me-Ph)3P]Pd(4-nBu-Ph)(Br)}2 and concept of blocking of the axial sites on Pd. b Model coupling reaction for optimizing ligands (ortho-substituent optimization) Pd(PPh3)4 was used due to insufficient yield with Pd2dba3/PPh3. c Crystal structure of {[(2-Bn-Ph)3P]Pd(4-OMe-Ph)(Br)}2 is consistent with the axial shielding ligand design principle. d % es and b/l ratio do not necessarily correlate as a function of ligand structure

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