Fig. 6 | Nature Communications

Fig. 6

From: Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma

Fig. 6

ITH of amplification and protein expression of CD274 (PD-L1) in ESCC. a Representative phylogeny for metastasis patterns of ESCC. b ITH of amplification in case ESCC012 and ESCC015. The bottom panel displays FISH validation of CD274 amplifications. c IHC staining of PD-L1 on samples from patients ESCC012 and ESCC015. Right bottom shows the absence of CD274 amplification using FISH analysis in ESCC015 T3. Scale bar: 50 μm. d PD-L1 protein expression in TC, IC, and tumor tissue

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