Fig. 1
Metabolic network of carbon source utilization. Group A substrates (in green frames) can be simultaneously utilized with Group B substrates (red frames), whereas substrates paired from Group A usually display diauxie. Only the major pathways are shown. The precursors of biomass components (amino acids marked with light brown frames and other components marked with orange frames) are classified into Pools a–d (marked with gray dashed line frames). The enzyme for the interconversion between Glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) is very efficient (Supplementary Table 1), so we approximate G6P/F6P as a single node for convenience. All Group A carbon sources enter the metabolic network through G6P/F6P, while Group B carbon sources enter the metabolic network from different points after glycolysis. Glycerol enters from the upper part of glycolysis but not G6P/F6P, thus we classify glycerol as a quasi-Group A carbon source (see Supplementary Note 1.4 for details)
