Fig. 3
Prognostic impact of the S-score. Overall survival curve plots for patients with less than 22% of S-score (plain curve) or more than 22% of S-score (dashed curve) in samples in the CIT, Bueno, TCGA, and Gordon series (a), all samples from the different series or the series restricted to epithelioid MPM (b), and our qRT-PCR validation dataset (c). Difference in median overall survival between patients with less or more 22% of S-score is indicated in red (b). The P values are based on a log-rank test and adjusted for the series when appropriate, and the number of patients (n) is indicated in each condition. d, e Forest plots of the overall survival hazard ratios (HRs) estimated using a multivariate Cox analysis adjusted for the series, integrating the E-score, S-score (d) and the histological types (e) for MPM samples from the CIT, Bueno, TCGA and Gordon series. The hazard ratios, 95% confidence intervals (CIs) and related Wald test P values are given for both components
