Fig. 5 | Nature Communications

Fig. 5

From: Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma

Fig. 5

Wnt1 represses chemokine genes on intratumoral DCs. a Volcano plot of differentially expressed genes (DEGs) in cDCs purified from Wnt1-overexpressing (Wnt1) vs control tumors (Empty). b Functional enrichment analysis (GO Biological Processes) of downregulated genes in Wnt1 vs. Empty tumor cDCs. c Expression heatmap (log2 normalized read counts) of differentially expressed chemokines. d Venn diagram of the overlap of predicted regulators by RNEA and ChEA. e String database interactions for differentially expressed chemokines, Ncor2 and Cebpb (network indicates evidence with medium confidence for all active interaction sources). Intratumoral lung cDCs were pooled from 3–4 mice (n = 3 pooled samples per group). d Arrows indicate up or downregulation of the differentially expressed regulators in Wnt1 vs Empty tumor cDCs. Sequencing data are available with the accession code GSE123068

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