Table 3 Previously unreported candidate variants identified using the WGS canids catalog
Associated phenotype | Gene/lncRNA | Definition/function | P value (Wald test) | Locus/position | Best candidate variation(s) |
|---|---|---|---|---|---|
Height (long legs) | ESR1 | Estrogen receptor 1 | 2.31E-11 | chr1:42085782-42573240 | Intronic SNPs |
Height, weight | LCORL a | Ligand-dependent nuclear receptor corepressor like | 4.04E-23 | chr3:91269525 | Indel in the last exon - lead to a STOP codon |
Drop ears | TCONS_00016758 a TCONS_00016759 a | Mutated lncRNA 29 kb downstream the last exon of MSRB3 | 7.63E-24 | chr10:8070103 | Exonic SNP in one lincRNA |
Weight | ZNF608 locus | Zinc finger protein 608 | 9.53E-15 | chr11:13906259-14081398 | SNPs 200 kb downstream the last exon |
Weight, bulky | R3HDM1 a | R3H domain containing 1 | 2.17E-13 | chr19:38303408 | CpG island - promoter |
Weight | ADAMTS9-AS a | ADAM metallopeptidase with thrombospondin type 1 motif 9 | 1.21E-13 | chr20:26692625 | exonic variant |
Bulky breed | HNF4G a | Hepatocyte nuclear factor 4 gamma | 1.95E-10 | chr29:23802662 | 3’UTR SNP |
