Table 5 Summary of XP-CLR and XP-EHH analyses between domestic dog breeds

From: Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology

Analysis

Gene

XP-CLR

XP-EHH (P valuea)

Long legs (Sighthounds)

ESR1

109.0b

1.16 (0.005)

Bulky

ADAMTSL3 locus

7.3c

0.94 (0.012)

ZNF608 locus

22.5b

1.02 (0.0054)

R3HDM1

NS

1.02 (0.0056)

HNF4G

4.7c

NS

ADAMTS9-AS

3.3c

NS

ACSL4

NS

NS

CFAX-locus 1

197.9b

1.66b

CFAX-locus 2 (IGSF1)

110.1b

2.18b

Height/weight (small breeds)

STC2

7.19c

1.99 (0.000039)

GHR

55.6b

1.17 (0.0025)

SMAD2

5.0c

0.84 (0.04)

HMGA2

173.7b

NS

IGF1

169.3b

NS

Height/weight (large breeds)

LCORL

14.6b

1.91 (0.0002)

IGF2BP2 locus

21.3b

1.37 (0.0025)

Drop ears

WIF1-MSRB3-lncRNA

224.3b

1.49 (0.00025)

Large ears

RIMS1-KCNQ5

452.6b

1.78 (0.00012)

  1. X chromosome was separated from autosomes to define the empirical top 1% of regions for both XP-CLR and XP-EHH. P values were not assigned for genes in the X chromosome (ACSL4, CFAX1, CFAX2)
  2. NS non significant
  3. aRank-based empirical P value
  4. bSignificant under 1% threshold
  5. cSignificant under 5% threshold
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