Fig. 2

DENV genome contains many conserved structural elements. a Plots show 100-nucleotide regions across four DENV genomes that have highly similar structures (gray), are highly double-stranded (black), and accumulate low levels of synonymous mutations (blue). Regions that fulfill two out of three of the above criteria are selected as consensus regions (purple) and are potentially functionally important. The structurally conserved regions from Fig. 1e are starred in blue. b A structure model of the DENV1 genome using NAI-MaP as experimental constraints, for the 16 consensus regions identified in a. The NAI-MaP reactivities and covariation information (green circles) are mapped onto the structures