Fig. 3
From: Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
Summary of side effect modeling results. Left: results of raw enrichment analysis (source data from Supplementary Table 2). Center: coefficients of the Mendelian genetics predictors in each of the 18 side effect models (source data from Supplementary Table 3). Right: coefficients of the GWAS genetics predictors in each of the 18 side effect models (source data from Supplementary Table 3). Coefficients from the regression models were exponentiated to obtain odds ratios. Along each row, circular points indicate odds ratios from the glm models; error bars are 95% confidence intervals from the glm models; large eight-pointed stars indicate odds ratios when the genetics predictors are selected as predictors in the glmnet models (which are built using feature selection, lasso regularization, and cross-validation). Small asterisks offset from the data indicate P-values of the the Fisher’s exact test (left) and P-values of the coefficients from the glm models (center and right) (*P < 0.05; **P < 0.01; ***P < 0.001)
