Fig. 4
From: Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

Results of cross validation analysis of contribution of genetics to predictive modeling. Gray bars show distribution of leave-one-target-set-out cross-validation AUC values from 1000 permutations of the genetic data; dashed line shows the cross-validation AUC value for a model omitting genetic information entirely; red line shows the cross-validation AUC of the regression model with real genetic data. The P-values are derived from the frequency of permutation runs that exceed the AUC of the true model. Source data are provided in Supplementary Table 4