Fig. 4 | Nature Communications

Fig. 4

From: Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

Fig. 4

Results of cross validation analysis of contribution of genetics to predictive modeling. Gray bars show distribution of leave-one-target-set-out cross-validation AUC values from 1000 permutations of the genetic data; dashed line shows the cross-validation AUC value for a model omitting genetic information entirely; red line shows the cross-validation AUC of the regression model with real genetic data. The P-values are derived from the frequency of permutation runs that exceed the AUC of the true model. Source data are provided in Supplementary Table 4

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