Fig. 7 | Nature Communications

Fig. 7

From: Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure

Fig. 7

Evaluation of modified analogs of 2 and 3. a Apparent KD values for 1–3 as determined by fluorescence intensity assays with 5′-Cy5-BsPreQ1-RS and 5′-AlexaFluor 647-TtPreQ1-RS RNA. Values are the mean ± s.d. (error bars) of three replicate measurements. b Quantification of termination efficiency of increasing concentrations of 2 (left) and 3 (right) in transcription termination assays of a DNA template containing the Ss PreQ1 riboswitch. Error bars indicate the standard deviation determined from three independent measurements. Source data are provided as a Source Data file. Gel images are provided in the Supplementary Information

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