Table 1 List of selected calcium channel blockers
From: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
Drugs | Class | Suggested primary target | Plasma half-life (human) | Crosses BBB |
|---|---|---|---|---|
Nimodipine | Dihydropyridine | L-Type channel P/Q channel | 1.7–9 h | Yes |
Isradipine | Dihydropyridine | L-Type channel | 8 h | Yes |
Felodipine | Dihydropyridine | L-Type channel T-Type channel | 8.5–19.7 h | Yes |
Verapamil | Non-dihydropyridine (phenylalkylamine) | L-Type channel B-Type channel P/Q channel | 2.8–7.4 h | No |
Diltiazem | Non-dihydropyridine (benzothiazepine) | L-Type channel | 3–4.5 h | Poor |
Amlodipine | Dihydropyridine | L-Type channel | 30–50 h | No |
Nifedipine | Dihydropyridine | L-Type channel | 2–7 ha | Yes |
Nicardipine | Dihydropyridine | L-Type channel | 8.6 h | Yes |
Clevidipine | Dihydropyridine | L-Type channel | 1 min | Yes |
(2–15 min) | ||||
Nisoldipine | Dihydropyridine | L-Type channel | 7–12 h | Yes |
