Fig. 2
From: Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics
Metabolic reaction network (MRN)-based recursive metabolite annotation. The numbers of annotated metabolites in Drosophila aging datasets: a positive and b negative modes. The left y-axis of the plot is the number of seed metabolites in each round, and the right y-axis of the plot is the cumulative number of annotated metabolites. c A Venn diagram showing the overlap of annotated metabolites in positive (red) and negative modes (blue). d Network diagrams demonstrating the distributions of annotated metabolites in round 0 (left, red), rounds 1–3 (middle, yellow), and rounds 4–19 (right, blue). e An example of initial seed metabolite (l-arginine) is given to demonstrate how MetDNA identifies 28 reaction-paired neighbor metabolites. f The numbers of annotated metabolites in different biological species and samples. The red, blue, and purple bars represent the results from the positive mode, negative mode, and the overlap between the positive and negative modes, respectively
