Fig. 6
From: Multiple myeloma immunoglobulin lambda translocations portend poor prognosis
IgL translocation co-occurs with hyperdiploid disease. a Heatmap of copy number alterations (CNA) in 777 newly diagnosed myelomas (rows) with genomic location (columns; 100 kb bins) labelled by chromosome (top). Hyperdiploid (HD) disease, and t(11;14), t(4;14), and t(14;16) translocations are annotated (left) as well as t(IgL) (right). b Frequency of common CNA in all newly diagnosed myeloma (gray) and myelomas with t(IgL) (black). **P < 0.01, Fisher’s exact test. c Progression-free (PFS; gray) and overall survival (OS; black) hazard ratios determined by multivariate survival analysis of common CNA and t(IgL) with 95% confidence intervals shown. d Kaplan-Meier survival analysis of patients with amplification of 1q [amp(1q)] (blue), without amp(1q) (gray), or both amp(1q) and t(IgL) (red). e Same as part d except shown for HD. P-values denote the survival difference between the specified CNA (blue) and the CNA + t(IgL) (red) relative to the ‘other’ group as determined by a Cox proportional hazards Wald’s test. Source data are provided as a Source Data file
