Fig. 2

Lower SV2A density in individuals with high severity depressive symptoms vs. HC subjects. a [¹¹C]UCB-J V_T in the dlPFC, ACC, and hippocampus across groups. The low severity group (in green; n = 14) consisted of participants with HAMD-17 scores <14 and the high severity group (in blue; n = 12) consisted of participants with HAMD-17 scores ≥14. Clinical subgroups are represented by different symbols; the low severity group consisted of MDD (n = 5), PTSD (n = 5) and MDD/PTSD (n = 4) subjects; the high severity group consisted of MDD (n = 6) and MDD/PTSD (n = 6) subjects. Group differences were assessed using MANOVA. Error bars represent standard deviation. b Representative axial, coronal, and sagittal parametric images of [¹¹C]UCB-J PET (V_T) scans registered to MR images in MNI space from a HC participant (top), low severity subject (middle) and high severity subject (bottom). Color bar represents V_T. dlPFC: dorsolateral prefrontal cortex: dlPFC, ACC:anterior cingulate cortex