Fig. 5
From: Lower synaptic density is associated with depression severity and network alterations
Relationship between SV2A density and functional connectivity, and cognitive function. a Lower performance on verbal memory task (International Shopping List-Delayed Recall) in clinical (n = 26) vs HC (n = 15) group. Error bars represent standard deviation. b Significant positive correlation between [11C]UCB-J VT in verbal memory across clinical subjects. c Trend level correlation between dlPFC SV2A density and verbal memory. d Lower performance on working memory task (one-back) in high severity clinical subjects (n = 12) vs. HC (n = 15). e Positive correlation between dlPFC ICD connectivity and working memory in high severity clinical subjects. f Negative correlation between dlPFC-PCC connectivity and working memory in high severity clinical subjects, suggesting that the greater the connectivity between core nodes of two typically anticorrelated networks (default mode and central executive networks), the greater the impairment in working memory. Correlations were assessed using Pearson’s r. dlPFC: dorsolateral prefrontal cortex, PCC: posterior cingulate cortex, ICD: intrinsic connectivity distribution
