Fig. 4 | Nature Communications

Fig. 4

From: Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

Fig. 4

Mitochondria-specific localization and in situ drug release in mitochondria. 4T1 cells were treated with RhB-labeled DT-PNs for 2, 4, 8, and 16 h, respectively. RhB (red channel) was utilized to label the polymer backbone. Mitotracker (green channel) was employed to co-stain mitochondria. Blue channel was originated from the emission of CPT itself. In the line-scan profiles, the red, blue, and green curves represent the fluorescence intensity from DT-PNs, CPT, and Mitotracker Green, respectively (scale bar, 5 μm)

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