Fig. 8 | Nature Communications

Fig. 8

From: Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

Fig. 8

In vivo biodistribution and cancer inhibition evaluation. a Time-lapse NIR fluorescence images of the tumor after tail vein injection with free ICG, NT-PNs and DT-PNs loaded with ICG, respectively. b Fluorescence images of major organs and tumors upon 24 h post-injection with three samples. c The biodistribution of free ICG, NT-PNs, and DT-PNs in mice determined by the averaged fluorescence intensity of each organ and tumor. The mean value was calculated by the t test (mean ± s.e.m. n = 5). **p < 0.01, ***p < 0.001, compared with the ICG group. d Representative photographs of mice after different treatments, the bottom tumor obtained from each treating group at 21 d. e Tumor volume and f survival rate of 4T1 tumor-bearing mice after different treatments. The mean value was calculated by the t test (mean ± s.e.m. n = 6). **p < 0.01, ***p < 0.001, compared with the PBS group. g Representative images of H&E stained tumor sections from different groups (scar bar, 50 μm)

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