Fig. 1 | Nature Communications

Fig. 1

From: Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5

Fig. 1

CEPsh glia share molecular similarities with astrocytes, including GLT-1 expression. a Schematic of C. elegans head (left), anterior is up, ventral is right. Cross-section of dashed area is enlarged (middle). Magenta, nerve ring; green, CEPsh glia; blue, muscle arms. Interactions of CEPsh glia processes with synapses are illustrated (inset). b Hierarchical clustering of mouse brain cells and CEPsh glia-expressed genes. x-axis dendrogram indicates the relationships among different cell types, y-axis dendrogram indicates relationships across individual genes. c Overrepresentation comparison of CEPsh glia-enriched genes with gene orthologs enriched in mouse glial cells. Normalized association values indicated by numbers and heatmap (FE, fold-enrichment). d Examples of CEPsh glia-enriched genes with orthologous genes enriched in mouse astrocytes. e Maximum intensity projections of deconvolved optical sections. glt-1 promoter expression in CEPsh glia (left; arrowheads), mir-228 glial promoter expression (middle; CEPsh glia, arrowheads); merged image (right). Scale bar, 8 μm

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