Fig. 1 | Nature Communications

Fig. 1

From: Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Fig. 1

Hypothetical paths that might link intrauterine exposures to DNA methylation, birthweight and later-life health outcomes. Red arrows summarise the paths that have motivated the analyses undertaken in this study (i.e. that maternal environmental exposures influence DNA methylation that in turn influences fetal growth and hence birthweight). The EWAS meta-analysis undertaken sought to identify methylation associated with birthweight. Blue arrows summarise other plausible paths, including that maternal exposures influence fetal growth first and it then influences DNA methylation or that maternal exposures may influence fetal growth/birthweight and later-life health outcomes through other pathways than DNA methylation

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