Fig. 4

LNK attenuated the IFN induced gene expression. a Pathway enrichment analysis: A375 cells with forced expression of LNK (LNK OE) were cultured either with (left panel) or without (right panel) IFN-γ (2000 U/ml). Enriched pathways of either upregulated (red color) or downregulated (blue color) genes in forced LNK expressing A375 melanoma cells are displayed with their p value. Pathway analysis was performed using [http://cpdb.molgen.mpg.de/]. b LNK attenuated the IFN-γ (2000 U/ml, 24 h) induced gene expression in A375 melanoma cells. Upper panel, LNK attenuated expression of IFN-γ interferon response genes. Middle panel, LNK attenuated IFN-γ induced expression of MHC class I genes. Lower panel, LNK attenuated IFN-γ induced expression of MHC class II genes