Fig. 7
From: Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9
Protospacer adjacent motif (PAM) recognition by the Cas9 orthologs. a Structure-based sequence alignment of the PAM-interacting regions of the Cas9 orthologs. b–f PAM recognition by Streptococcus pyogenes Cas9 (SpCas9) (PDB: 4UN3) (b), Staphylococcus aureus Cas9 (SaCas9) (PDB: 5CZZ) (c), Corynebacterium diphtheriae Cas9 (CdCas9) (d), Campylobacter jejuni Cas9 (CjCas9) (PDB: 5X2G) (e), and Francisella novicida Cas9 (FnCas9) (PDB: 5B2O) (f). In SpCas9, the insertion between the β6 and β7 is omitted for clarity. The PAMs are highlighted in purple. Hydrogen bonds are shown as dashed lines. Water molecules are depicted as red spheres
