Fig. 8
From: Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis
Sequential reactions combining chemo-catalysis and bio-catalysis. A 1,4-addition reaction was followed by a nitro group reduction, and then an asymmetric reduction of the keto-product mediated by ADH101, all in one-pot and enabled by aqueous TPGS-750-M. The enantiomeric excess (ee) was determined by chiral HPLC after N-acetylation of 5
