Fig. 1

Copy number variations in the CHOICE versus TCGA NSCLC data. a SQCC focal amplifications. b SQCC focal deletions. c ADC focal amplifications. d ADC focal deletions. The GISTIC 2.0 algorithm was used to identify significantly recurrent copy number gains and losses in ADC and SQCC population, respectively. The q values for amplification (a, c) and deletions (b, d) in the CHOICE study were plotted against the q values from the TCGA datasets. CNVs with q values <0.25 were significant. Representative genes in focal regions were used whenever possible. Red dots: significant focal events only in the CHOICE cohort (ADC); blue dots: significant focal events only in TCGA dataset (SQCC). Red dashed line: q value cutoffs. Source data are provided as a Source Data file