Fig. 3
From: Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Regional plots of exemplar colorectal cancer risk loci. In the main panel, −log10P-values (y-axis) of the SNPs are shown according to their chromosomal positions (x-axis). The colour intensity of each symbol reflects the extent of LD with the top SNP: white (r2 = 0) through to dark red (r2 = 1.0), with r2 estimated from EUR 1000 Genomes data. Genetic recombination rates (cM/Mb) are shown with a light blue line. Physical positions are based on GRCh37 of the human genome. Where available, the upper panel shows Hi-C contacts from HT29 or LoVo. The lower panel shows the chromatin state segmentation track from the Roadmap Epigenomics project (colonic mucosa, rectal mucosa, sigmoid colon), and HCT116. Also shown are the relative positions of genes and transcripts mapping to each region of association. a rs12255141 (10q25.2); b rs12979278 (19q13); c rs2735940 (5p15); d rs7398375 (12q13.3)
