Table 1 Summary results for the new colorectal cancer risk loci in Europeans
From: Association analyses identify 31 new risk loci for colorectal cancer susceptibility
SNP | Cytoband | Position (bp, GRCh37) | Risk/alt allele | RAF | OR | 95% CI | P-value | BFDP | I2 (%) | P het | Average info score |
|---|---|---|---|---|---|---|---|---|---|---|---|
rs61776719 | 1p34.3 | 38,461,319 | C/A | 0.45 | 1.07 | (1.05; 1.10) | 2.19 × 10−10 | 1.98 × 10−3 | 1 | 0.44 | 0.89 |
rs12143541 | 1p32.3 | 55,247,852 | G/A | 0.15 | 1.10 | (1.06; 1.13) | 9.44 × 10−10 | 7.44 × 10−3 | 16 | 0.28 | 0.95 |
rs11692435 | 2q11.2 | 98,275,354 | G/A | 0.90 | 1.12 | (1.07; 1.16) | 1.22 × 10−8 | 0.079 | 29 | 0.14 | 0.97 |
rs11893063 | 2q33.1 | 199,601,925 | A/G | 0.47 | 1.07 | (1.04; 1.09) | 9.34 × 10−9 | 0.069 | 43 | 0.04 | 0.96 |
rs7593422 | 2q33.1 | 200,131,695 | T/A | 0.55 | 1.07 | (1.05; 1.10) | 3.56 × 10−11 | 3.50 × 10−4 | 15 | 0.28 | 0.99 |
rs9831861 | 3p21.1 | 53,088,285 | G/T | 0.59 | 1.07 | (1.05; 1.09) | 4.17 × 10−10 | 3.72 × 10−3 | 0 | 0.87 | 0.99 |
rs12635946 | 3q13.2 | 112,916,918 | C/T | 0.62 | 1.08 | (1.06; 1.10) | 1.02 × 10−11 | 1.03 × 10−4 | 11 | 0.33 | 0.97 |
rs17035289 | 4q24 | 106,048,291 | T/C | 0.83 | 1.10 | (1.07; 1.13) | 2.73 × 10−10 | 2.30 × 10−3 | 0 | 0.95 | 1.00 |
rs75686861 | 4q31.21 | 145,621,328 | A/G | 0.10 | 1.12 | (1.08; 1.16) | 1.76 × 10−9 | 0.014 | 0 | 0.49 | 0.92 |
rs2070699 | 6p24.1 | 12,292,772 | T/G | 0.48 | 1.07 | (1.04; 1.09) | 3.88 × 10−9 | 0.031 | 29 | 0.14 | 0.95 |
rs3131043 | 6p21.33 | 30,758,466 | G/A | 0.43 | 1.07 | (1.05; 1.1) | 2.67 × 10−8 | 0.159 | 60 | 0.01 | 0.91 |
rs9271770 | 6p21.32 | 32,594,248 | A/G | 0.81 | 1.08 | (1.05; 1.11) | 3.60 × 10−8 | 0.192 | 0 | 0.91 | 0.93 |
rs6928864 | 6q21 | 105,966,894 | C/A | 0.91 | 1.13 | (1.09; 1.19) | 1.37 × 10−8 | 0.094 | 0 | 0.73 | 0.98 |
rs10951878 | 7p12.3 | 46,926,695 | C/T | 0.49 | 1.06 | (1.04; 1.09) | 1.10 × 10−8 | 0.080 | 0 | 0.65 | 0.99 |
rs3801081 | 7p12.3 | 47,511,161 | G/A | 0.68 | 1.08 | (1.06; 1.11) | 2.00 × 10−11 | 1.96 × 10−4 | 50 | 0.01 | 1.00 |
rs1412834 | 9p21.3 | 22,110,131 | T/C | 0.50 | 1.08 | (1.06; 1.11) | 4.13 × 10−14 | 5.05 × 10−7 | 14 | 0.30 | 1.00 |
rs4450168 | 11p15.4 | 10,286,755 | C/A | 0.17 | 1.10 | (1.06; 1.13) | 1.24 × 10−8 | 0.079 | 0 | 0.81 | 0.86 |
rs7398375 | 12q13.3 | 57,540,848 | C/G | 0.72 | 1.09 | (1.06; 1.13) | 3.91 × 10−10 | 3.23 × 10−3 | 0 | 0.93 | 0.83 |
rs12427600 | 13q13.3 | 37,460,648 | C/T | 0.24 | 1.09 | (1.06; 1.11) | 5.43 × 10−11 | 5.01 × 10−4 | 0 | 0.81 | 0.99 |
rs45597035 | 13q22.1 | 73,649,152 | A/G | 0.64 | 1.08 | (1.05; 1.10) | 2.16 × 10−10 | 1.94 × 10−3 | 0 | 0.53 | 0.96 |
rs1330889 | 13q22.3 | 78,609,615 | C/T | 0.87 | 1.11 | (1.07; 1.14) | 6.50 × 10−10 | 5.25 × 10−3 | 0 | 0.59 | 0.97 |
rs7993934 | 13q34 | 111,074,915 | T/C | 0.65 | 1.08 | (1.05; 1.10) | 3.03 × 10−11 | 2.94 × 10−4 | 0 | 0.55 | 0.99 |
rs4776316 | 15q22.31 | 67,007,813 | A/G | 0.73 | 1.08 | (1.05; 1.10) | 1.11 × 10−8 | 0.076 | 22 | 0.21 | 0.95 |
rs10152518 | 15q23 | 68,177,162 | G/A | 0.19 | 1.08 | (1.05; 1.11) | 3.24 × 10−8 | 0.180 | 0 | 0.84 | 0.97 |
rs7495132 | 15q26.1 | 91,172,901 | T/C | 0.12 | 1.11 | (1.07; 1.14) | 7.92 × 10−10 | 6.34 × 10−3 | 29 | 0.14 | 0.99 |
rs61336918 | 16q23.2 | 80,007,266 | A/T | 0.29 | 1.09 | (1.06; 1.12) | 2.04 × 10−12 | 2.14 × 10−5 | 0 | 0.90 | 0.99 |
rs1078643 | 17p12 | 10,707,241 | A/G | 0.77 | 1.09 | (1.06; 1.12) | 4.14 × 10−11 | 3.81 × 10−4 | 0 | 0.56 | 0.92 |
rs285245 | 19p13.11 | 16,420,817 | T/C | 0.11 | 1.11 | (1.07; 1.15) | 3.71 × 10−8 | 0.195 | 2 | 0.42 | 0.91 |
rs12979278 | 19q13.33 | 49,218,602 | T/C | 0.53 | 1.07 | (1.05; 1.09) | 6.11 × 10−10 | 5.35 × 10−3 | 15 | 0.28 | 0.96 |
rs6066825 | 20q13.13 | 47,340,117 | A/G | 0.65 | 1.10 | (1.08; 1.13) | 3.82 × 10−17 | 5.67 × 10−10 | 0 | 0.49 | 0.99 |
rs3787089 | 20q13.33 | 62,316,630 | C/T | 0.32 | 1.07 | (1.05; 1.10) | 5.80 × 10−9 | 0.043 | 0 | 0.80 | 0.96 |
Associations previously only identified in Asian populations | |||||||||||
rs639933 | 5q31.1 | 134,467,751 | C/A | 0.38 | 1.07 | (1.05; 1.10) | 1.14 × 10−9 | 9.50 × 10−3 | 0 | 0.73 | 0.98 |
rs6933790 | 6p21.1 | 41,672,769 | T/C | 0.83 | 1.10 | (1.07; 1.14) | 3.65 × 10−10 | 3.03 × 10−3 | 21 | 0.23 | 0.91 |
rs704017 | 10q22.3 | 80,819,132 | G/A | 0.60 | 1.10 | (1.08; 1.13) | 2.96 × 10−16 | 4.15 × 10−9 | 23 | 0.21 | 0.95 |
rs12255141 | 10q25.2 | 114,294,892 | G/A | 0.10 | 1.11 | (1.07; 1.15) | 2.97 × 10−9 | 0.022 | 0 | 0.81 | 0.96 |
rs10849438 | 12p13.31 | 6,412,036 | G/T | 0.12 | 1.12 | (1.08; 1.16) | 1.04 × 10−10 | 9.49 × 10−4 | 21 | 0.23 | 0.95 |
rs73975588 | 17p13.3 | 816,741 | A/C | 0.87 | 1.10 | (1.06; 1.13) | 8.71 × 10−9 | 0.058 | 33 | 0.11 | 0.97 |
rs9797885 | 19q13.2 | 41,873,001 | G/A | 0.71 | 1.08 | (1.05; 1.10) | 2.77 × 10−10 | 2.43 × 10−3 | 0 | 0.70 | 0.99 |
rs6055286 | 20p12.3 | 7,718,045 | A/G | 0.15 | 1.11 | (1.07; 1.14) | 9.69 × 10−11 | 8.61 × 10−4 | 50 | 0.02 | 0.97 |
rs2179593 | 20q13.12 | 42,660,286 | A/C | 0.72 | 1.07 | (1.05; 1.10) | 4.62 × 10−9 | 0.035 | 0 | 0.67 | 0.97 |
