Fig. 1
From: Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery
Symptoms and histopathology in infant rabbits infected with Shigella flexneri. a, b Representative images of animals (top) and colon (bottom) inoculated with phosphate-buffered saline (PBS) (a) or S. flexneri (b). Scale bar, 2 cm. c, d Representative images of hematoxylin- and eosin-stained colonic sections from animals inoculated with PBS (c) or S. flexneri (d). Dotted lines delineate the colon. Double arrows indicate the width of the colon section with massive swelling in d. Brackets indicate the width of connective tissues with edema (E). VL indicates vascular lesions with red blood cells. Insets: high magnification of epithelial cells (EC) with fenestration in d. Scale bars, 100 μm. e Histopathology scores of VLs, edema (E), and percentage of epithelial fenestration (EF). Statistical analysis, unpaired t test. Shigella flexneri (wild type (WT)) vs. mock (PBS): VL, ****P < 0.0001; E, ****P < 0.0001; EF, ****P < 0.0001. Source data are provided as a Source Data file
