Fig. 6
From: Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery
Symptoms and histopathology in absence of cell-to-cell spread. a Representative images of animals (top) and colon (bottom) inoculated with the ΔicsA mutant. Arrows indicate tarnished fur. Scale bar, 2 cm. b Representative image of hematoxylin- and eosin-stained colonic sections from animals inoculated with the ΔicsA mutant. Dotted lines delineate the colon. E, edema; VLs, vascular lesions. Insets: (top) high magnification of red blood cells (RBCs) indicative of VLs and (bottom) high magnification of epithelial cells (ECs). Scale bar, 100 μm. c Histopathology scores of VLs) and heterophil infiltration (HI). Statistical analysis: unpaired Student’s t test. ΔicsA vs. mock (phosphate-buffered saline (PBS): VLs, **P < 0.01; ***HI, P < 0.05. d Graphs showing the percentage of epithelial fenestration (EF) and weight loss (WL). Statistical analysis, unpaired t test. ΔicsA vs. S. flexneri (wild type (WT)): EF, ****P < 0.0001; WL, ****P < 0.0001. Source data are provided as a Source Data file
